Claire L. Bingham

Claire L. Bingham is a physician-scientist and translational researcher known for work on pulmonary arterial hypertension, vascular biology, and immune mechanisms in lung disease. She has held positions at major academic medical centers and federal research institutions, collaborating across clinical, laboratory, and regulatory environments. Her career bridges patient care, clinical trials, and basic science, with emphasis on biomarker discovery, therapeutic development, and interdisciplinary training.

Early life and education

Born and raised in a family with ties to Boston, New Haven, Connecticut, and Washington, D.C., she pursued undergraduate studies at Yale University and medical training at Harvard Medical School, with residency and fellowship experiences at Massachusetts General Hospital, Brigham and Women's Hospital, and clinical research rotations at the National Institutes of Health and Johns Hopkins Hospital. During her early career she trained under mentors affiliated with American Thoracic Society, Association of American Physicians, and the Howard Hughes Medical Institute, and participated in programs connected to National Heart, Lung, and Blood Institute and Food and Drug Administration initiatives. Her formative mentors included faculty from Perelman School of Medicine at the University of Pennsylvania, University of California, San Francisco, and Yale School of Medicine.

Medical and research career

She served on faculty at institutions such as Johns Hopkins University School of Medicine, the University of Pennsylvania Perelman School of Medicine, and engaged in research at the National Institutes of Health Clinical Center. Her clinical roles spanned pulmonary and critical care services at centers including Massachusetts General Hospital, Hospital of the University of Pennsylvania, and tertiary referral programs associated with Mount Sinai Health System and Cleveland Clinic. In research, she established collaborations with investigators at Columbia University Irving Medical Center, Stanford University School of Medicine, University of California, San Diego, and University of Pittsburgh School of Medicine. She contributed to multicenter consortia funded by agencies such as the National Heart, Lung, and Blood Institute, National Institute of Allergy and Infectious Diseases, and international partnerships involving European Respiratory Society, British Heart Foundation, and networks linked to Canadian Institutes of Health Research.

Contributions to pulmonary hypertension and immunology

Her scientific contributions include elucidating pathobiology of pulmonary arterial hypertension through studies of endothelial dysfunction, inflammation, and autoimmunity, intersecting with research on systemic sclerosis, HIV-associated pulmonary hypertension, and connective tissue disease–related vascular disorders. She investigated cytokine signaling pathways involving interleukin-6, tumor necrosis factor-alpha, and transforming growth factor beta in preclinical models developed in laboratories at National Institutes of Health and academic centers such as Yale School of Medicine and Harvard Medical School. Her translational work integrated techniques from labs at Massachusetts Institute of Technology and Broad Institute, including high-throughput genomics, proteomics, and single-cell sequencing used in studies with collaborators from Cold Spring Harbor Laboratory and Sanger Institute. She contributed to clinical trials involving therapies targeting the endothelin pathway, prostacyclin analogs, and phosphodiesterase-5 inhibitors in coordination with industry partners including Pfizer, Bayer, and Gilead Sciences and regulatory review interactions with the Food and Drug Administration. Her immunology research connected to studies of adaptive immunity in lung disease with investigators from Dana-Farber Cancer Institute, The Rockefeller University, and Fred Hutchinson Cancer Center, and she co-authored guidelines developed by the American College of Chest Physicians and European Society of Cardiology for pulmonary vascular disease.

Awards and honors

Her recognitions include institutional awards from Johns Hopkins University, research grants and fellowships from the National Institutes of Health and American Heart Association, early career honors from the American Thoracic Society, and invited lectures at meetings organized by the International Society for Heart and Lung Transplantation and European Respiratory Society. She received collaborative science awards from translational programs involving National Heart, Lung, and Blood Institute and translational medicine honors linked to consortiums with Wellcome Trust and Canadian Institutes of Health Research. She has been a visiting scholar at centers including Oxford University, Cambridge University, and Karolinska Institutet.

Selected publications and patents

Her peer-reviewed work appears in journals such as The New England Journal of Medicine, The Lancet, Nature Medicine, Science Translational Medicine, Journal of Clinical Investigation, Circulation, American Journal of Respiratory and Critical Care Medicine, European Respiratory Journal, and Blood. Representative publications cover biomarker identification, mechanistic studies of vascular remodeling, and clinical trial results integrating immunomodulatory strategies. She is listed as an inventor on patents related to biomarker assays, therapeutic targets in pulmonary vascular remodeling, and diagnostic platforms developed in collaboration with university technology transfer offices and industry partners including Johnson & Johnson and AbbVie. Selected coauthors and collaborators include investigators from Brigham and Women's Hospital, Vanderbilt University Medical Center, Mount Sinai Health System, University of Michigan Medical School, and Duke University School of Medicine.

Category:Physicians Category:Pulmonologists Category:Immunologists