Journal of Clinical Investigation

Journal of Clinical Investigation
Title	Journal of Clinical Investigation
Discipline	Medicine
Abbreviation	J. Clin. Investig.
Publisher	American Society for Clinical Investigation
Country	United States
Frequency	Biweekly
History	1924–present
Openaccess	Hybrid

Journal of Clinical Investigation is a peer-reviewed medical journal publishing biomedical research and clinical studies. Founded in the United States in 1924, it has featured contributions from researchers associated with institutions such as Harvard University, Johns Hopkins University, Massachusetts General Hospital, Mayo Clinic, and University of Pennsylvania. The journal has published influential work connected to investigators from National Institutes of Health, Stanford University, University of California, San Francisco, Columbia University, and Yale University.

History

The journal was established in 1924 amid developments at institutions like Rockefeller University, New York University, University of Chicago, Washington University in St. Louis, and University of Michigan. Early editorial figures were linked to organizations such as American Association of Immunologists, American Physiological Society, Royal Society, Lasker Foundation, and Guggenheim Fellowship recipients. Throughout the 20th century the journal published landmark papers from laboratories at Cleveland Clinic, University of California, Los Angeles, Cornell University, Duke University, and Vanderbilt University Medical Center. Postwar expansion saw interactions with agencies including Food and Drug Administration, World Health Organization, National Cancer Institute, Howard Hughes Medical Institute, and Centers for Disease Control and Prevention. In the 21st century, editorial and publishing practices engaged with initiatives from Public Library of Science, Wellcome Trust, Bill & Melinda Gates Foundation, European Commission, and National Science Foundation.

Scope and Content

The journal covers clinical and translational research spanning topics investigated at centers such as Dana–Farber Cancer Institute, Fred Hutchinson Cancer Center, Scripps Research Institute, Karolinska Institutet, and Imperial College London. Articles include original research, reviews, and commentaries relevant to programs at Massachusetts Institute of Technology, Princeton University, University of Oxford, Cambridge University, and McGill University. Typical subject areas overlap with work conducted at Broad Institute, Cold Spring Harbor Laboratory, Medical Research Council, Institut Pasteur, and Max Planck Society labs. The journal has published studies involving disease models used at Walter Reed Army Institute of Research, Centers for Disease Control and Prevention, Mount Sinai Health System, University of Toronto, and Karolinska University Hospital.

Editorial Leadership and Peer Review

Editorial leadership historically included editors and advisory board members affiliated with Harvard Medical School, Johns Hopkins School of Medicine, Perelman School of Medicine, Vanderbilt University School of Medicine, and University of California School of Medicine. The peer-review process draws reviewers from networks spanning American Society for Clinical Investigation, Association of American Physicians, European Society of Clinical Investigation, International Society for Clinical Research, and academic societies such as American Heart Association and American Association for Cancer Research. Editorial policies have been influenced by guidelines from Committee on Publication Ethics, International Committee of Medical Journal Editors, World Association of Medical Editors, NIH Office of Research Integrity, and funder mandates from Wellcome Trust and Bill & Melinda Gates Foundation.

Publication and Access Model

Published on a biweekly schedule by the American Society for Clinical Investigation, the journal operates a hybrid open-access and subscription model similar to arrangements used by publishers such as Oxford University Press, Elsevier, Springer Nature, Wiley-Blackwell, and Cambridge University Press. Author fees, institutional subscriptions, and agreements with consortia such as Jisc and HINARI inform access. The journal’s policies align with public-access expectations from National Institutes of Health, European Research Council, Wellcome Trust, Horizon 2020, and mandates enforced by national funders like UK Research and Innovation and Canada Foundation for Innovation.

Abstracting and Indexing

The journal is indexed in major bibliographic databases and services including PubMed, MEDLINE, Web of Science, Scopus, Embase, Google Scholar, and Clarivate Analytics. Citation metrics are tracked by platforms such as Journal Citation Reports, Scimago Journal Rank, CrossRef, ORCID, and Dimensions. Institutional repositories at Harvard University, MIT, Stanford University, Yale University, and Columbia University frequently mirror deposit policies. Library cataloging systems like Library of Congress, OCLC, WorldCat, and national libraries coordinate holdings.

Impact and Reception

The journal has influenced clinical research agendas at centers including Massachusetts General Hospital, Johns Hopkins Hospital, Brigham and Women’s Hospital, UCLA Medical Center, and Mayo Clinic Hospital. Its articles have been cited in policy documents from World Health Organization, European Medicines Agency, Food and Drug Administration, National Institutes of Health, and Centers for Disease Control and Prevention. Awards and recognition connected to contributions published include Lasker Award, Nobel Prize, Breakthrough Prize, Canada Gairdner Awards, and Royal Society Fellows. The journal’s impact factor and reputation are discussed in analyses by Nature, Science, The Lancet, New England Journal of Medicine, and BMJ.

Category:Medical journals Category:Publications established in 1924