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| Michelle Monje | |
|---|---|
| Name | Michelle Monje |
| Fields | Neurology; Neuro-oncology; Neuroscience |
| Workplaces | Stanford University; Lucile Packard Children's Hospital; Dana-Farber Cancer Institute; Broad Institute |
| Alma mater | Harvard University; Columbia University; Stanford University |
| Known for | Diffuse intrinsic pontine glioma research; pediatric brain tumor immunotherapy; synaptic signaling in glioma |
Michelle Monje
Michelle Monje is a neurologist and neuro-oncologist known for research on pediatric brain tumors, particularly diffuse intrinsic pontine glioma, and for translating basic neuroscience into clinical trials and immunotherapy approaches. She holds faculty positions at Stanford University and practices at Lucile Packard Children's Hospital, combining laboratory investigation with patient care and advocacy for pediatric oncology. Her work bridges molecular neurobiology, cancer genomics, immunotherapy, and clinical trial design.
Monje completed undergraduate studies at Harvard University and clinical and graduate training at Columbia University and Stanford University, including residency and fellowship programs associated with Massachusetts General Hospital, NewYork-Presbyterian Hospital, and Lucile Packard Children's Hospital. During postgraduate training she worked with investigators at Dana-Farber Cancer Institute, Broad Institute, Cold Spring Harbor Laboratory, and collaborators from Children's Hospital Boston. Her formation involved mentors from Harvard Medical School, Columbia University Vagelos College of Physicians and Surgeons, and the Stanford University School of Medicine, and she participated in research networks including Pediatric Oncology Group, Children's Oncology Group, and consortia linked to National Cancer Institute programs.
Monje's laboratory at Stanford University focuses on the cellular and molecular mechanisms of high-grade gliomas in children, integrating approaches from neuroscience, cancer biology, genomics, epigenetics, and immunology. She has investigated oncogenic drivers such as histone H3K27M alterations characterized in studies from teams at Cold Spring Harbor Laboratory, Dana-Farber Cancer Institute, and Memorial Sloan Kettering Cancer Center, and has collaborated with researchers at University of California, San Francisco, Johns Hopkins University, and University of Pennsylvania. Her group published work on tumor microenvironment interactions involving neurons and glia, building on concepts studied at Salk Institute, Max Planck Institute, and Massachusetts Institute of Technology. Monje's research employed techniques developed at Broad Institute, Wellcome Sanger Institute, European Molecular Biology Laboratory, and laboratories using CRISPR methods pioneered at University of California, Berkeley and Broad Institute facilities; her projects were informed by high-throughput sequencing standards from Genomics England and datasets from The Cancer Genome Atlas and other consortia. She has collaborated with clinicians and basic scientists from Children's Hospital of Philadelphia, Seattle Children's Research Institute, and UCSF Benioff Children's Hospital to translate discoveries into preclinical models and phase I/II clinical trials, coordinating with regulatory frameworks at Food and Drug Administration and funding agencies such as National Institutes of Health, National Science Foundation, American Brain Tumor Association, and philanthropic partners like St. Baldrick's Foundation.
In clinical practice at Lucile Packard Children's Hospital, Monje treats children with brain tumors including diffuse intrinsic pontine glioma, medulloblastoma, and other pediatric neuro-oncologic conditions, working within multidisciplinary teams involving pediatric neurosurgery groups from Rady Children's Hospital, Cincinnati Children's Hospital Medical Center, and Texas Children's Hospital. She designs and leads clinical trials in partnership with investigators at Dana-Farber Cancer Institute, Memorial Sloan Kettering Cancer Center, and Children's Hospital Los Angeles, and engages with cooperative groups such as Children's Oncology Group and international trial networks including European Society for Paediatric Oncology and International Society of Paediatric Oncology. Her care model integrates standards from American Academy of Pediatrics, survivorship frameworks linked to Children's Oncology Group Long-Term Follow-Up Guidelines, and supportive services from institutions like Ronald McDonald House Charities and St. Jude Children's Research Hospital.
Monje has received recognition from organizations including awards and fellowships associated with American Academy of Neurology, Society for Neuroscience, American Association for Cancer Research, American Society of Clinical Oncology, and specialized pediatric honors from American Pediatric Society. She has been supported by grants from National Institutes of Health, career awards linked to National Cancer Institute, and philanthropic prizes from groups such as Alex's Lemonade Stand Foundation and CureSearch for Children's Cancer. Her laboratory and translational efforts have been highlighted by media outlets like The New York Times, Nature, Science, and The Lancet Oncology.
Monje is active in public communication and advocacy for pediatric brain tumor research, participating in panels with National Institutes of Health officials, briefing members of United States Congress committees, and speaking at forums hosted by World Health Organization and United Nations health initiatives. She collaborates with nonprofit organizations including St. Baldrick's Foundation, National Brain Tumor Society, CureSearch for Children's Cancer, and Alex's Lemonade Stand Foundation to promote funding, patient registries, and policy change. Monje has appeared in documentaries and interviews alongside journalists from NPR, BBC, CNN, and in scientific outreach at institutions such as Smithsonian Institution, American Museum of Natural History, and universities including Yale University and Princeton University.
Category:American neurologists Category:Neuro-oncologists Category:Stanford University School of Medicine faculty