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| Circulation Foundation | |
|---|---|
| Name | Circulation Foundation |
| Formation | 2010 |
| Type | Nonprofit organization |
| Headquarters | London |
| Region served | Global |
| Leader title | Chief Executive Officer |
Circulation Foundation The Circulation Foundation is an international nonprofit organization focused on vascular health, public outreach, research funding, and clinical guideline dissemination. Founded in 2010, it engages with hospitals, universities, research institutes, and patient groups to promote best practices in cardiovascular and peripheral vascular care across Europe, North America, Asia, and Africa.
The foundation operates across multiple domains including clinical research, medical education, patient advocacy, and health policy implementation, connecting institutions such as Mayo Clinic, Johns Hopkins Hospital, Imperial College London, Karolinska Institutet, University of Oxford, Massachusetts General Hospital, Stanford University School of Medicine, Harvard Medical School, University of Toronto, UCSF Medical Center, University College London Hospitals NHS Foundation Trust, Addenbrooke's Hospital, Guy's and St Thomas' NHS Foundation Trust, Cleveland Clinic, Mount Sinai Hospital, Northwestern Medicine, University of Melbourne, The University of Tokyo Hospital, National University Hospital (Singapore), Sao Paulo State University, Aga Khan University Hospital, Groote Schuur Hospital, Charité – Universitätsmedizin Berlin, Hôpital Pitié-Salpêtrière, Hospital Clínic de Barcelona, AP-HP, Toronto General Hospital, Royal Prince Alfred Hospital, Singapore General Hospital, and Sheba Medical Center.
The foundation funds translational projects and clinical trials, supports guideline development with bodies like World Health Organization, European Society of Cardiology, American Heart Association, International Society on Thrombosis and Haemostasis, Royal College of Physicians, Royal College of Surgeons of England, American College of Cardiology, and partners with professional societies including Vascular Society of Great Britain and Ireland, European Vascular Association, Society for Vascular Surgery, Asian Society for Vascular Surgery, and Latin American Society of Angiology and Vascular Surgery.
Established in 2010 by clinicians and philanthropists with ties to Wellcome Trust, Bill & Melinda Gates Foundation, The Rockefeller Foundation, and The Robert Wood Johnson Foundation, the foundation emerged after collaborative meetings at Royal Society symposia and conferences such as European Society of Cardiology Congress, American Heart Association Scientific Sessions, International Stroke Conference, Transcatheter Cardiovascular Therapeutics, and Vascular Annual Meeting. Founding partners included representatives from Oxford University Hospitals NHS Foundation Trust, Johns Hopkins University, Imperial College London, UCSF, and Mayo Clinic. Early initiatives drew on frameworks from Cochrane Collaboration, National Institute for Health and Care Excellence, National Institutes of Health, Canadian Institutes of Health Research, and Australian National Health and Medical Research Council.
The organization expanded through regional offices and memoranda of understanding with institutions such as European Commission, United Nations Development Programme, World Bank Group, Gavi, the Vaccine Alliance, and major academic consortia including Wellcome Trust Clinical Research Facility, NIHR, EMBL-EBI, Institut Pasteur, and Max Planck Society.
The foundation's mission centers on reducing morbidity from vascular disease through research funding, education, and advocacy. Core programs include fellowship awards tied to Fulbright Program-style exchanges, seed grants modeled on NIH Director's Pioneer Award mechanisms, multicenter trial support similar to ClinicalTrials.gov registries, and continuing professional development aligned with standards from Accreditation Council for Continuing Medical Education and European Accreditation Council for Continuing Medical Education.
Training initiatives partner with teaching hospitals and universities such as Addenbrooke's Hospital, Guy's and St Thomas', Charité, Hôpital Necker–Enfants Malades, Hospital Clínic de Barcelona, Mount Sinai, Cleveland Clinic, and programs engage patient advocacy groups like British Heart Foundation, American Heart Association, Heart and Stroke Foundation of Canada, European Heart Network, and World Federation of Hemophilia.
Governance comprises a board with members drawn from institutions including Mayo Clinic, Harvard Medical School, Oxford, Karolinska Institutet, Imperial College, Johns Hopkins, University of Toronto, Stanford University, and regulatory advisers from Medicines and Healthcare products Regulatory Agency, European Medicines Agency, US Food and Drug Administration, and Health Canada. Funding sources span philanthropic foundations such as Wellcome Trust and Bill & Melinda Gates Foundation, governmental bodies like UK Research and Innovation, National Institutes of Health, Canadian Institutes of Health Research, corporate grants from medical device and pharmaceutical companies including Medtronic, Boston Scientific, Abbott Laboratories, Bayer AG, Pfizer, as well as charitable trusts and individual donors.
Financial oversight follows policies similar to Charity Commission for England and Wales guidance, auditing practices paralleling International Financial Reporting Standards, and conflict-of-interest policies informed by World Health Organization frameworks.
The foundation reports outcomes through peer-reviewed publications in journals such as The Lancet, New England Journal of Medicine, Circulation, Journal of the American College of Cardiology, European Heart Journal, BMJ, Nature Medicine, JAMA, Annals of Surgery, Stroke (journal), and Vascular Medicine. Program evaluation uses metrics comparable to Consolidated Standards of Reporting Trials and GRADE (guideline), with impact assessments referencing datasets from Global Burden of Disease Study, UK Biobank, Framingham Heart Study, NHANES, Danish National Patient Registry, and Swedish National Quality Registries.
The Circulation Foundation has formal collaborations with international organizations and academic centers, including World Health Organization, European Commission, United Nations, Wellcome Trust, Bill & Melinda Gates Foundation, NIH, NIHR, European Society of Cardiology, American Heart Association, Society for Vascular Surgery, Cochrane Collaboration, Cambridge University Hospitals, Oxford University Hospitals, Imperial College Healthcare NHS Trust, Johns Hopkins Medicine, Mayo Clinic, Cleveland Clinic, Stanford Medicine, Harvard Medical School, University of Toronto, University of Melbourne, Karolinska Institutet, Charité, Institut Pasteur, Max Planck Society, GAVI, and regional ministries of health across Europe, Africa, and Asia.
Critiques have arisen over industry funding relationships involving firms like Medtronic, Boston Scientific, Abbott Laboratories, Bayer AG, Pfizer, and questions about influence on guideline panels reminiscent of debates surrounding Lancet and BMJ disclosures. Other controversies echo wider sector debates linked to NIH-industry partnerships, transparency issues noted in investigations by ProPublica and reporting in outlets like The Guardian and The New York Times, and tensions similar to those encountered by Royal College of Physicians and American College of Cardiology when reconciling clinical recommendations with sponsor-supported research agendas.
Category:Non-profit medical organizations