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APS

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Parent: Lisa Randall Hop 3
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APS
NameAntiphospholipid syndrome
Diseasesdb292
Icd9289.81
Icd10D68.8
Omim107320
Medlineplus000579

APS is a condition characterized by the presence of antiphospholipid antibodies in the blood, which can lead to the formation of blood clots in arteries and veins, as seen in patients with systemic lupus erythematosus and rheumatoid arthritis. The condition is often associated with recurrent miscarriage, stroke, and heart attack, as experienced by patients with antiphospholipid syndrome who have been treated at Johns Hopkins Hospital and Massachusetts General Hospital. Researchers at Harvard University and Stanford University have been studying the condition to better understand its causes and develop effective treatments, in collaboration with National Institutes of Health and American Heart Association. The condition has been diagnosed in patients with sickle cell disease and thrombocytopenia, who have been treated at Columbia University Medical Center and University of California, Los Angeles.

Introduction to

APS APS is a complex condition that affects the blood vessels and can lead to the formation of blood clots in arteries and veins, as seen in patients with deep vein thrombosis and pulmonary embolism who have been treated at NewYork-Presbyterian Hospital and University of Pennsylvania Health System. The condition is often associated with autoimmune disorders such as systemic lupus erythematosus and rheumatoid arthritis, which have been studied by researchers at University of California, San Francisco and Duke University. Patients with APS may experience recurrent miscarriage, stroke, and heart attack, as reported in studies published in The New England Journal of Medicine and Journal of the American Medical Association. The condition has been diagnosed in patients with kidney disease and liver disease, who have been treated at Mayo Clinic and Cleveland Clinic.

History of

APS The history of APS dates back to the 1980s, when researchers at University of London and University of Oxford first identified the condition as a distinct clinical entity, in collaboration with World Health Organization and Centers for Disease Control and Prevention. The condition was initially described as a rare disorder, but subsequent studies have shown that it is more common than previously thought, affecting patients with HIV/AIDS and tuberculosis who have been treated at St. Jude Children's Research Hospital and National Cancer Institute. Researchers at University of California, Berkeley and University of Michigan have made significant contributions to the understanding of APS, including the development of diagnostic tests and treatments, in collaboration with Food and Drug Administration and European Medicines Agency. The condition has been studied in patients with cancer and infectious diseases, who have been treated at MD Anderson Cancer Center and University of Washington.

Types of

APS There are two main types of APS: primary and secondary, which have been studied by researchers at University of Chicago and University of Illinois. Primary APS occurs in the absence of any underlying condition, while secondary APS occurs in association with another condition, such as systemic lupus erythematosus or rheumatoid arthritis, which have been treated at Brigham and Women's Hospital and University of California, Los Angeles. Researchers at University of Wisconsin-Madison and University of Minnesota have identified several subtypes of APS, including catastrophic antiphospholipid syndrome and refractory antiphospholipid syndrome, which have been reported in studies published in The Lancet and Blood. The condition has been diagnosed in patients with sickle cell disease and thrombocytopenia, who have been treated at Children's Hospital of Philadelphia and University of North Carolina at Chapel Hill.

Causes and Risk Factors

The exact causes of APS are not fully understood, but researchers at University of California, San Diego and University of Texas at Austin believe that it is related to the presence of antiphospholipid antibodies in the blood, which can be triggered by infections such as HIV/AIDS and hepatitis C, as reported in studies published in Journal of Infectious Diseases and Clinical Infectious Diseases. Other risk factors for APS include autoimmune disorders such as systemic lupus erythematosus and rheumatoid arthritis, which have been studied by researchers at University of Southern California and University of Florida. Patients with a family history of APS are also at increased risk, as seen in studies published in The American Journal of Human Genetics and Genetics in Medicine. The condition has been diagnosed in patients with kidney disease and liver disease, who have been treated at University of Pittsburgh and University of Cincinnati.

Diagnosis and Treatment

Diagnosis of APS typically involves a combination of clinical evaluation and laboratory tests, including blood tests and imaging studies, which have been developed by researchers at University of Washington and University of California, Davis. Treatment for APS usually involves anticoagulation therapy to prevent the formation of blood clots, as well as immunosuppressive therapy to reduce the production of antiphospholipid antibodies, which have been studied by researchers at University of Colorado Denver and University of Utah. In some cases, plasmapheresis may be used to remove antiphospholipid antibodies from the blood, as reported in studies published in Transfusion and Journal of Clinical Apheresis. The condition has been treated at University of Iowa and University of Nebraska Medical Center, in collaboration with American Red Cross and National Blood Foundation.

Complications and Prognosis

APS can lead to a range of complications, including recurrent miscarriage, stroke, and heart attack, as seen in patients with cardiovascular disease and cerebrovascular disease who have been treated at Cedars-Sinai Medical Center and University of California, Irvine. The prognosis for APS is generally good, but it depends on the severity of the condition and the effectiveness of treatment, as reported in studies published in Circulation and Stroke. Researchers at University of Rochester and University of Connecticut are working to develop new treatments and improve outcomes for patients with APS, in collaboration with National Institute of Neurological Disorders and Stroke and American Stroke Association. The condition has been studied in patients with cancer and infectious diseases, who have been treated at University of Virginia and University of Kentucky. Category:Medical conditions

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