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| Stanford Cognitive and Systems Neuroscience Laboratory | |
|---|---|
| Name | Stanford Cognitive and Systems Neuroscience Laboratory |
| Established | 2000s |
| Director | Karl Deisseroth |
| Location | Stanford University, Palo Alto, California |
| Fields | Cognitive neuroscience; Systems neuroscience; Neuroengineering |
| Affiliations | Stanford University; Howard Hughes Medical Institute |
Stanford Cognitive and Systems Neuroscience Laboratory The Stanford Cognitive and Systems Neuroscience Laboratory is a research group based at Stanford University that integrates experimental, theoretical, and technological approaches to study brain function. The laboratory connects work across institutions such as Howard Hughes Medical Institute, National Institutes of Health, and collaborators at Massachusetts Institute of Technology and University of California, San Francisco to address questions in cognition, behavior, and neural circuits. Research from the laboratory has influenced fields represented by awards like the Breakthrough Prize in Life Sciences, the Lasker Award, and the Gruber Neuroscience Prize.
The laboratory focuses on mechanisms of perception, decision-making, memory, and psychiatric disorders with roots in traditions at Cold Spring Harbor Laboratory, Max Planck Institute for Brain Research, and Salk Institute for Biological Studies. It operates within the broader ecosystem including departments such as Stanford School of Medicine, Department of Psychology, Stanford University, and centers like the Wu Tsai Neurosciences Institute and the Stanford Neurosciences Institute. Leadership draws on paradigms established by researchers from Columbia University, Harvard University, and Yale University and interacts with consortia linked to BRAIN Initiative and Human Connectome Project.
The laboratory pursues questions in neural circuit dynamics, linking cellular mechanisms and behavior studied in models from Mus musculus to nonhuman primates associated with laboratories at Princeton University and University College London. Major themes include sensory processing inspired by work at University of Cambridge, cognitive control influenced by studies at University of Oxford, and psychiatric disease mechanisms complementary to research at McLean Hospital and Broad Institute. Translational emphases connect to clinical programs at Stanford Health Care and policy efforts involving National Institute of Mental Health and Food and Drug Administration.
Experimental platforms include optogenetics developed alongside groups at University of California, Berkeley, in vivo calcium imaging pioneered in collaboration with investigators from Harvard Medical School, and high-density electrophysiology built on tools from Allen Institute for Brain Science. Computational approaches reference models from MIT Computer Science and Artificial Intelligence Laboratory, machine learning advances from Google DeepMind, and theoretical frameworks related to work at Princeton Neuroscience Institute. The lab employs viral vectors tested against standards from Centers for Disease Control and Prevention and imaging equipment similar to systems at National Institute of Neurological Disorders and Stroke.
Notable projects include circuit mapping efforts that parallel initiatives at Allen Institute for Brain Science and connectomics strategies akin to studies at Janelia Research Campus. Findings have implications for understanding disorders treated at Stanford Medicine Children's Health and insights that inform pharmacology research at Eli Lilly and Company and Pfizer. The lab has reported advances in activity-dependent labeling related to methods from Howard Hughes Medical Institute researchers and linked electrophysiological signatures to behavior in paradigms used at Brown University and University of Chicago.
Faculty and staff include investigators with training from institutions such as Massachusetts Institute of Technology, Harvard University, Yale University, Princeton University, Columbia University, University of California, San Diego, University of Pennsylvania, Johns Hopkins University, and University of Cambridge. Postdoctoral fellows and graduate students collaborate with mentors who have held positions at Salk Institute for Biological Studies, Max Planck Society, and Karolinska Institutet. Administrative and technical core personnel coordinate with offices at Stanford School of Medicine and funding offices linked to National Science Foundation and National Institutes of Health.
The laboratory maintains collaborations with clinical partners at Stanford Health Care, basic science partners at Howard Hughes Medical Institute, and industry partnerships with companies like Google DeepMind, Neuralink, and Genentech. Academic collaborations include joint projects with University of California, San Francisco, Massachusetts Institute of Technology, Columbia University, Harvard Medical School, and international partners at Max Planck Institute for Biological Cybernetics and University College London. Grant and consortium participation includes programs funded by BRAIN Initiative, Human Frontier Science Program, and foundations such as the Simons Foundation and Gordon and Betty Moore Foundation.
Laboratory infrastructure uses core facilities comparable to those at Stanford Neurosciences Institute and imaging suites modeled after installations at Cold Spring Harbor Laboratory and Janelia Research Campus. Resources include high-performance computing clusters like those at National Energy Research Scientific Computing Center, viral vector production suites akin to facilities at Salk Institute for Biological Studies, and animal facilities accredited similarly to those at University of Oxford and University of Cambridge. Training and education draw on curricula from Stanford School of Medicine and workshops connected to conferences such as the Society for Neuroscience annual meeting and symposia at Gordon Research Conferences.
Category:Neuroscience laboratories