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| Seth L. Schein | |
|---|---|
| Name | Seth L. Schein |
| Fields | Chemistry, Biochemistry, Structural Biology |
| Workplaces | Columbia University, University of Chicago, University of Wisconsin–Madison |
| Alma mater | Dartmouth College, Yale University |
| Known for | Protein crystallography, Enzyme mechanism, Bacterial pathogenesis |
Seth L. Schein is an American chemist and structural biologist known for contributions to protein crystallography, enzymology, and studies of macromolecular structure. He has held faculty positions at major research universities and contributed to understanding enzyme mechanisms, bacterial toxins, and protein assembly through X-ray crystallography and biochemical analysis. His work intersects with investigations into antibiotic targets, virulence factors, and protein engineering.
Schein studied chemistry and related fields at Dartmouth College and pursued graduate studies at Yale University, where he trained in structural methods alongside researchers affiliated with Cold Spring Harbor Laboratory, Brookhaven National Laboratory, and faculty connected to Howard Hughes Medical Institute. During his formative years he engaged with techniques developed at institutions such as Massachusetts Institute of Technology, Harvard University, and Stanford University, aligning with contemporaries from laboratories at University of California, Berkeley, Princeton University, and California Institute of Technology. His early mentors and collaborators included scientists associated with National Institutes of Health, National Science Foundation, and professional societies like the American Chemical Society.
Schein has served on faculties at universities including University of Wisconsin–Madison, University of Chicago, and Columbia University, participating in departments linked to American Association for the Advancement of Science, Biophysical Society, and interdisciplinary centers collaborating with Yale School of Medicine and New York Presbyterian Hospital. He taught courses influenced by curricula from University of Michigan, Johns Hopkins University, and Cornell University while supervising students who later joined laboratories at University of California, San Francisco, Scripps Research Institute, and Max Planck Institute affiliates. His administrative and editorial roles intersected with publishers and organizations such as Nature Publishing Group, Proceedings of the National Academy of Sciences, and Journal of Biological Chemistry.
Schein's research emphasized protein crystallography, with structural studies resonant with work carried out at European Molecular Biology Laboratory, Argonne National Laboratory, and beamlines supported by Advanced Photon Source. He elucidated enzyme active sites and catalytic mechanisms akin to investigations in MRC Laboratory of Molecular Biology, Weizmann Institute of Science, and Institut Pasteur, contributing to models used by researchers at University of Cambridge, ETH Zurich, and University of Oxford. His studies of bacterial proteins and virulence factors linked to research on Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa, informing antimicrobial target discovery pursued by teams at GlaxoSmithKline, Pfizer, and Novartis. Schein applied biochemical kinetics and mutagenesis strategies similar to those of groups at Imperial College London, Karolinska Institutet, and Seoul National University to probe substrate specificity and protein–protein interactions, contributing data integrated into structural repositories maintained by RCSB PDB and collaborative networks involving EMBL-EBI and Protein Data Bank consortia. His interdisciplinary projects bridged efforts by investigators from Cold Spring Harbor Laboratory, Salk Institute, and Broad Institute on topics such as toxin assembly, enzyme inhibition, and macromolecular architecture.
Schein received recognition from professional organizations including awards and fellowships associated with American Chemical Society, Biophysical Society, and Gordon Research Conferences, and was invited to deliver lectures at venues such as Cold Spring Harbor Laboratory, Royal Society of Chemistry, and Howard Hughes Medical Institute symposia. His career has been supported by grants from agencies including National Institutes of Health, National Science Foundation, and foundations similar to Guggenheim Foundation and Simons Foundation, and he has been elected to roles within societies like the American Association for the Advancement of Science and editorial boards for journals connected to American Society for Biochemistry and Molecular Biology.
- Structural and mechanistic studies of enzyme active sites published in journals affiliated with Proceedings of the National Academy of Sciences, Journal of Biological Chemistry, and Nature Structural & Molecular Biology with coauthors from University of California, San Diego, Yale University, and Columbia University. - Crystallographic analyses of bacterial virulence factors in outlets related to EMBO Journal, Cell, and Science collaborating with researchers from Max Planck Institute, Institut Pasteur, and University of Cambridge. - Reviews on protein assembly and enzymology appearing alongside contributions from investigators at Scripps Research Institute, University of Illinois Urbana–Champaign, and University of Toronto in journals published by Nature Publishing Group and Oxford University Press.
Category:American chemists Category:Structural biologists