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| PERUKI | |
|---|---|
| Name | PERUKI |
| Type | Collaborative research network |
| Founded | 2015 |
| Headquarters | United Kingdom |
| Region served | United Kingdom, Ireland, Australasia, Europe |
| Membership | Hospital emergency departments, research-active clinicians, allied health professionals |
PERUKI
PERUKI is a multinational clinical research network linking emergency medicine and paediatric emergency care institutions across the United Kingdom, Ireland, and international partners. It fosters multicentre studies, quality improvement, and trainee-led research by connecting clinical sites, academic departments, and professional organisations such as Royal College of Paediatrics and Child Health, Royal College of Emergency Medicine, Health Research Authority, National Institute for Health Research, and international counterparts like Australian and New Zealand Paediatric Emergency Research Network and Paediatric Emergency Research in the United States (PERUS)?. The network promotes evidence generation through collaboration among clinicians, research fellows, and institutions including Great Ormond Street Hospital, St Thomas' Hospital, Temple Street Children's University Hospital, Alder Hey Children's NHS Foundation Trust, and university departments such as University College London, University of Edinburgh, Queen's University Belfast, and Trinity College Dublin.
PERUKI operates as a distributed consortia model linking paediatric and emergency medicine sites, research units, and trainee groups. It interfaces with funders and regulators like Wellcome Trust, Medical Research Council, National Institute for Health and Care Excellence, and European Medicines Agency to facilitate multicentre trials, observational studies, and audits. The network brings together clinicians from institutions such as Great Ormond Street Hospital, Royal Belfast Hospital for Sick Children, Bristol Royal Hospital for Children, Manchester University NHS Foundation Trust, Leeds Teaching Hospitals NHS Trust, and partnerships with organisations including Paediatric Emergency Research Networks, European Society for Paediatric Research, and International Federation for Emergency Medicine.
PERUKI emerged amid growing recognition of the need for coordinated paediatric emergency research across the United Kingdom and Ireland following initiatives by bodies such as National Institute for Health Research and policy reports from Department of Health and Social Care. Early stakeholder meetings involved representatives from Royal College of Paediatrics and Child Health, Royal College of Emergency Medicine, academic groups at University College London, University of Glasgow, and trainee organisations like British Association for Emergency Medicine Trainees and Paediatric Emergency Research in the United Kingdom and Ireland Trainees (PERUKI Trainees)?. The network scaled through pilot multicentre projects using sites at Alder Hey Children's NHS Foundation Trust, Birmingham Women's and Children's NHS Foundation Trust, and Sheffield Children's NHS Foundation Trust, securing seed support from charities such as Vaccine Confidence Project? and funders including Wellcome Trust and National Institute for Health Research. Subsequent growth involved formal links with international collaborators including Australian and New Zealand Paediatric Emergency Research Network, Canadian Paediatric Society, and academic centres at Harvard Medical School, McGill University, and Karolinska Institutet.
Membership encompasses paediatric emergency departments, research-active clinicians, trainees, and allied health professionals affiliated with NHS trusts, university hospitals, and private institutions. Key institutional participants have included Royal Manchester Children's Hospital, King's College Hospital, Royal London Hospital, Royal Victoria Infirmary, Evelina London Children's Hospital, and St George's Hospital. The governance structure draws on advisory input from leaders at Royal College of Paediatrics and Child Health and Royal College of Emergency Medicine, academic chairs from University of Oxford, University of Cambridge, Imperial College London, and representatives from funders such as National Institute for Health Research. Collaborative nodes interface with regional research networks including NIHR Clinical Research Network, Health and Care Research Wales, and Health Research Board.
PERUKI coordinates multicentre observational studies, randomized controlled trials, feasibility pilots, quality improvement collaboratives, and trainee-led audits. Studies have leveraged site networks to evaluate clinical questions relevant to paediatric emergency care seen at institutions like Great Ormond Street Hospital and Royal Belfast Hospital for Sick Children, and to inform guideline development referenced by National Institute for Health and Care Excellence and professional bodies. The network provides study design support, statistical collaboration from groups at University of Manchester and University of Bristol, training workshops in research methodology linked to Wellcome Trust Clinical Research Training, and platforms for trainee research presented at meetings such as Royal College of Paediatrics and Child Health Annual Conference and Royal College of Emergency Medicine Scientific Meeting. PERUKI facilitates data sharing agreements with hospital trusts and supports patient and public involvement through partnerships with charities like Great Ormond Street Hospital Charity and YoungMinds.
PERUKI's governance typically includes an executive committee, scientific advisory board, and local site principal investigators from hospitals such as Alder Hey Children's NHS Foundation Trust and Birmingham Children's Hospital. Oversight aligns with regulatory frameworks including Health Research Authority approvals and ethical review by NHS Research Ethics Committees and institutional review boards at universities like Queen Mary University of London and University of Glasgow. Funding streams have comprised grants from National Institute for Health Research, competitive awards from Wellcome Trust, charitable support from organisations such as Children's Hospital Charity (name varies) and project-specific sponsorship from universities and industry partners engaged with paediatric therapeutics and diagnostics.
PERUKI has enabled rapid recruitment to multicentre studies that influenced clinical practice at centres including Great Ormond Street Hospital, Evelina London Children's Hospital, and Royal Manchester Children's Hospital, and contributed to guideline updates by National Institute for Health and Care Excellence and statements from Royal College of Paediatrics and Child Health. Collaborations extend internationally with networks such as Australian and New Zealand Paediatric Emergency Research Network, Canadian Paediatric Society research groups, and academic partnerships with Harvard Medical School, McGill University, and Karolinska Institutet. The network's trainee-led model has parallels with initiatives by National Institute for Health and Care Research Trainees Collaborative Group and has supported career development of clinicians who later joined faculties at University of Oxford, Imperial College London, University College London, and University of Edinburgh.
Category:Medical research networks