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| National Institute for Cardiovascular Outcomes Research | |
|---|---|
| Name | National Institute for Cardiovascular Outcomes Research |
| Formation | 2008 |
| Type | Research institute |
| Headquarters | University of Oxford |
| Leader title | Director |
National Institute for Cardiovascular Outcomes Research The National Institute for Cardiovascular Outcomes Research is a clinical outcomes research institute focused on cardiovascular disease, acute coronary syndrome, heart failure, arrhythmia and valve disease. It produces national registries, quality indicators and benchmarking tools that inform NHS policy, hospital performance and guideline development by bodies such as National Institute for Health and Care Excellence and professional societies including the British Cardiovascular Society, European Society of Cardiology and American College of Cardiology. The institute collaborates with academic partners at the University of Oxford, University College London and Imperial College London and with international organizations such as the World Health Organization, European Medicines Agency and International Consortium for Health Outcomes Measurement.
The institute maintains clinical registries and publishes performance metrics for procedures like percutaneous coronary intervention, coronary artery bypass grafting, transcatheter aortic valve implantation and cardiac electrophysiology. Its outputs inform commissioners such as Clinical commissioning group predecessors, regulators including Care Quality Commission and guideline panels convened by National Institute for Health and Care Excellence and the Royal College of Physicians. Data are used by trusts like Guy's and St Thomas' NHS Foundation Trust, Royal Brompton and Harefield NHS Foundation Trust and Oxford University Hospitals NHS Foundation Trust for quality improvement. The institute engages with patient groups such as British Heart Foundation, Heart UK and Arrhythmia Alliance.
The institute was established during healthcare reforms and evidence movements that included actors like Department of Health and Social Care, Health and Social Care Act 2012 debates and the modernisation initiatives championed by figures linked to NHS England. Early registries were influenced by international models from Swedish Heart Surgery Register, Society of Thoracic Surgeons and the European Society of Cardiology EURObservational Research Programme. Key institutional partners during development included the University of Oxford, University College London Hospitals NHS Foundation Trust and the National Institute for Health Research. The institute expanded registry scope in response to advances from manufacturers such as Medtronic, Edwards Lifesciences and Boston Scientific and device approvals overseen by the Medicines and Healthcare products Regulatory Agency.
Governance includes academic leadership from university faculties and oversight by boards with representatives from NHS England, Academy of Medical Royal Colleges, professional societies like the Society for Cardiothoracic Surgery in Great Britain and Ireland and patient advocates from British Heart Foundation. Funding streams combine grants from the National Institute for Health Research, project contracts with NHS England, philanthropy from foundations and collaborative industry research agreements with companies such as Johnson & Johnson and Abbott Laboratories. Ethical review and data governance align with committees comparable to those at Health Research Authority and standards promoted by Information Commissioner's Office.
Major programs include registries for percutaneous coronary intervention influenced by benchmarks like those from Society for Cardiovascular Angiography and Interventions, cardiac surgery registries following examples from the Society of Thoracic Surgeons, transcatheter valve registries paralleling initiatives in European Association of Percutaneous Cardiovascular Interventions data efforts, and heart failure audits similar to those run by Get With The Guidelines. The institute supports randomized registry trials akin to designs used by TASTE trial and comparative effectiveness studies inspired by work from Duke Clinical Research Institute and Yale School of Medicine. It provides timely dashboards used by hospital boards at institutions including St Thomas' Hospital, Royal Liverpool University Hospital and King's College Hospital.
The institute employs methods from epidemiology and health services research exemplified by researchers at London School of Hygiene & Tropical Medicine, Harvard T.H. Chan School of Public Health and Johns Hopkins Bloomberg School of Public Health. Data linkage incorporates national datasets such as Hospital Episode Statistics and mortality linkage with Office for National Statistics. Risk adjustment models are developed with approaches used by EuroSCORE and GRACE risk score teams. Data security and pseudonymisation follow frameworks promoted by Information Commissioner's Office and exemplar programs at NHS Digital. Statistical methods reference standards from CONSORT and STROBE reporting guidance; analytic work often draws on expertise associated with MRC Biostatistics Unit.
Reports have documented temporal trends in mortality, complications and service variation that informed policy responses by NHS England and guideline updates issued by European Society of Cardiology and National Institute for Health and Care Excellence. Findings influenced regional service reconfigurations similar to reforms at Barts Health NHS Trust and Mersey Regional Cardiac Network. Publications have contributed evidence cited in health technology assessments from National Institute for Health and Care Excellence and cost-effectiveness analyses used by NICE appraisal committees and external agencies like Scottish Medicines Consortium.
The institute partners with academic centres including University of Oxford, Imperial College London, University College London and international collaborators such as European Society of Cardiology, American College of Cardiology and World Health Organization. Collaborative projects include registry harmonisation efforts with Society for Cardiovascular Angiography and Interventions, device surveillance studies with manufacturers like Edwards Lifesciences and multinational research consortia modelled on International Consortium for Health Outcomes Measurement initiatives. Patient and public involvement is organised with charities such as British Heart Foundation and advocacy groups including Arrhythmia Alliance.
Category:Cardiology research institutes