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France BioImaging

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France BioImaging
NameFrance BioImaging
Formation2014
TypeResearch Infrastructure
HeadquartersParis
Region servedFrance

France BioImaging is a national research infrastructure for biomedical imaging that coordinates advanced microscopy and imaging technologies across French research institutions. It supports access to state-of-the-art platforms, promotes technology development, and fosters training for researchers from academia and industry. The initiative interfaces with European and international projects to integrate resources and standards across imaging infrastructures.

Overview

France BioImaging connects platforms that host modalities such as confocal microscopy, super-resolution microscopy, cryo-electron microscopy, magnetic resonance imaging, and light-sheet microscopy across institutions like Institut Pasteur, Centre national de la recherche scientifique, Commissariat à l'énergie atomique et aux énergies alternatives, Collège de France, and university hospitals in Paris. The infrastructure liaises with European initiatives such as European Molecular Biology Laboratory, European Research Infrastructure Consortium, Euro-BioImaging, and interacts with global projects at Massachusetts Institute of Technology, Max Planck Society, National Institutes of Health, Wellcome Trust, and European Commission programs. Key stakeholder networks include platform managers from Université Paris-Saclay, Sorbonne Université, Université de Strasbourg, Aix-Marseille Université, and regional research hospitals like Assistance publique - Hôpitaux de Paris. France BioImaging emphasizes interoperability with metadata standards developed by groups around ELIXIR, Global BioImaging, Open Microscopy Environment, and initiatives tied to Horizon 2020.

History and Development

The development of the infrastructure followed strategic national roadmaps influenced by reports from entities such as INSERM, INRIA, CNRS, and recommendations from advisory bodies associated with Ministère de l'Enseignement supérieur, de la Recherche et de l'Innovation. Initial coordination began through consortia involving laboratories at Institut Curie, Institut Pasteur de Lille, and regional centers at Université Grenoble Alpes and Université de Bordeaux. Milestones included alignment with the European roadmap through engagement with Euro-BioImaging and participation in frameworks related to Horizon 2020 and Horizon Europe. Development phases brought together technology hubs from CEA, academic departments at Université de Lyon, and hospital research units at Hôpital Pitié-Salpêtrière. Advisory input drew on international best practices from Karolinska Institutet, ETH Zurich, and Johns Hopkins University.

Organization and Governance

The governance structure incorporates representatives from major research organizations such as CNRS, INSERM, CEA, and universities including Université Grenoble Alpes and Sorbonne Université. A scientific advisory board includes experts linked to institutions such as European Molecular Biology Laboratory, Max Planck Institute for Biophysical Chemistry, University of Cambridge, and Imperial College London. Coordination offices operate in concert with regional nodes hosted at academic centers like Université de Strasbourg, Université de Lille, and Université de Bordeaux. Management aligns with national funding agencies including Agence Nationale de la Recherche and partners in collaborative agreements with European Research Council stakeholders. Interfaces with clinical imaging units include collaborations with Institut Mutualiste Montsouris and tertiary centers like Centre Hospitalier Universitaire de Nantes.

Facilities and Network

The network comprises imaging platforms located in research centers at Institut Pasteur, Institut Curie, CEA Saclay, Université de Montpellier, and Université Toulouse Paul Sabatier. Facilities span technologies provided by manufacturers and developers associated with ZEISS, Leica Microsystems, Thermo Fisher Scientific, and specialized units linked to EMBL-style laboratories. Regional hubs in cities such as Lyon, Bordeaux, Strasbourg, Grenoble, and Marseille offer access to high-end instruments including cryo-electron microscopes, super-resolution systems, multimodal imaging suites, and MRI scanners used by clinical partners like Hospices Civils de Lyon. The network integrates core facilities from translational centers such as Institut Gustave Roussy and federates resources across multidisciplinary departments at École Normale Supérieure.

Research and Services

France BioImaging supports research programs in cell biology, developmental biology, neuroscience, cancer biology, and regenerative medicine involving teams at Institut Pasteur, Institut Curie, INSERM Unit 980, and university laboratories across Université Paris-Saclay and Université de Lyon. Services include instrument access, image acquisition pipelines, image analysis workflows built upon ImageJ, Fiji (software), OMERO, and computational resources linked to infrastructures like Compute Canada-style centers and national high-performance computing provided by GENCI. Collaborative projects have interfaced with consortia such as Human Cell Atlas, BLUEPRINT project, and disease-focused networks including European Cancer Organisation. Technology development efforts draw on partnerships with groups at Max Planck Society, EMBL, and corporate R&D groups within Thermo Fisher Scientific.

Training and Outreach

The training program organizes courses and workshops in partnership with academic training units from Université de Strasbourg, Université de Paris', and research schools linked to École Polytechnique and École Normale Supérieure de Lyon. Outreach activities include participation in scientific conferences such as Microscopy & Microanalysis Conference, EMBO Conference, Gordon Research Conferences, and national meetings hosted by Société Française de Microscopie. Educational collaborations link with initiatives from ELIXIR training platforms, summer schools with EMBL, and exchange programs involving Karolinska Institutet and Harvard University laboratories.

Funding and Collaborations

Funding sources combine national grants from Agence Nationale de la Recherche, institutional support from CNRS and INSERM, and European funding through Horizon 2020 and Horizon Europe calls. Collaborative agreements involve partnerships with Euro-BioImaging, university hospitals including AP-HP, and research centers such as Institut Curie and Institut Pasteur de Lille. Industry collaborations include joint projects with firms like ZEISS, Leica Microsystems, and Thermo Fisher Scientific as well as participation in consortia tied to translational initiatives supported by European Investment Bank instruments and philanthropic funders such as Wellcome Trust and Gordon and Betty Moore Foundation.

Category:Research infrastructures