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| Duke Clinical and Translational Science Institute | |
|---|---|
| Name | Duke Clinical and Translational Science Institute |
| Established | 2008 |
| Type | Research institute |
| Affiliation | Duke University |
| Location | Durham, North Carolina, United States |
Duke Clinical and Translational Science Institute is an academic research institute affiliated with Duke University and located in Durham, North Carolina. It serves as a hub for clinical and translational research connecting entities such as Duke University School of Medicine, Duke University Health System, National Institutes of Health, National Center for Advancing Translational Sciences, and regional partners. The institute supports investigators involved with programs linked to Clinical and Translational Science Awards, National Institutes of Health Clinical Center, U.S. Food and Drug Administration, Centers for Disease Control and Prevention, and major philanthropic organizations.
Founded in 2008 amid national initiatives led by the National Institutes of Health and the Clinical and Translational Science Awards Program, the institute emerged from collaborations among Duke University School of Medicine, Duke University Health System, Duke Global Health Institute, and local partners in Durham County, North Carolina. Early leadership included senior faculty with ties to Johns Hopkins University, Harvard Medical School, Vanderbilt University Medical Center, and University of California, San Francisco. Over time the institute expanded through grant awards from entities such as the National Heart, Lung, and Blood Institute, National Cancer Institute, National Institute of Allergy and Infectious Diseases, and partnerships with industry partners like Pfizer, GlaxoSmithKline, and Johnson & Johnson. Key milestones paralleled initiatives at Massachusetts General Hospital, Brigham and Women's Hospital, Mayo Clinic, and Cleveland Clinic as translational research networks grew nationally.
The institute's mission aligns with priorities set by the National Center for Advancing Translational Sciences, the NIH Roadmap, and institutional strategies from Duke University and Duke University Health System. Objectives emphasize accelerating translation of discoveries from laboratories associated with Duke University School of Medicine and the Duke University School of Nursing into clinical applications involving partners such as Duke Regional Hospital, Duke Raleigh Hospital, and community health organizations in Wake County. Strategic goals mirror frameworks used by University of California, Los Angeles, Stanford University, Yale School of Medicine, and University of Pennsylvania Perelman School of Medicine to promote clinical trial efficiency, regulatory science aligned with the U.S. Food and Drug Administration, and community-engaged research modeled after programs at Howard University and Morehouse School of Medicine.
Governance structures involve leadership drawn from Duke University School of Medicine, Duke University Health System, and administrative models similar to Johns Hopkins Medicine, Massachusetts General Hospital, and Vanderbilt University Medical Center. Oversight includes executive directors, scientific directors, and advisory boards with representatives from National Institutes of Health, National Science Foundation, and corporate partners such as Roche, Novartis, and AbbVie. Committees coordinate with institutional review boards like those at Duke University Office of Clinical Research and external stakeholders including North Carolina Department of Health and Human Services, Durham County Board of Commissioners, and nonprofit funders such as the Bill & Melinda Gates Foundation and the Robert Wood Johnson Foundation.
Research spans translational pipelines informed by disciplines and centers at Duke University School of Medicine, Duke Cancer Institute, Duke Clinical Research Institute, Duke Cardiovascular Research Center, and Duke Global Health Institute. Programs include pragmatic clinical trials, precision medicine initiatives similar to All of Us Research Program, biostatistics cores modeled after Fred Hutchinson Cancer Research Center, and informatics platforms interoperable with standards from Health Level Seven International, Observational Health Data Sciences and Informatics, and the National COVID Cohort Collaborative. Disease-focused efforts partner with programs at the National Cancer Institute, American Heart Association, Alzheimer's Association, and Centers for Disease Control and Prevention on projects addressing oncology, cardiology, infectious diseases, and mental health. Pilot funding and translational accelerators mirror initiatives at Broad Institute and Scripps Research to move discoveries into trials sponsored by industry partners such as Merck and contract research organizations like IQVIA.
Training programs integrate curricula from Duke University School of Medicine, Duke University School of Nursing, and graduate programs at Graduate School of Duke University. Offerings include KL2 and TL1 career development awards patterned on NIH mechanisms, certificate programs in clinical research administration akin to programs at Columbia University, mentorship networks similar to those at University of Michigan Medical School, and workshops on regulatory science aligned with U.S. Food and Drug Administration guidance. Trainees collaborate with clinical sites including Duke University Hospital, community clinics in Chapel Hill, and partner institutions such as North Carolina Central University and East Carolina University.
The institute maintains formal collaborations with federal agencies like the National Institutes of Health, Centers for Medicare & Medicaid Services, and Agency for Healthcare Research and Quality, academic partners such as University of North Carolina at Chapel Hill, North Carolina State University, Wake Forest School of Medicine, and international affiliates including Karolinska Institutet and University of Oxford. Industry collaborations include pharmaceutical companies like AstraZeneca, Bristol Myers Squibb, and biotechnology firms similar to Genentech. Community engagement involves partnerships with local health departments, patient advocacy groups such as American Cancer Society and American Diabetes Association, and foundations including the Kaiser Family Foundation.
Physical assets include clinical research units located within Duke University Hospital, outpatient research spaces affiliated with Duke Raleigh Hospital, laboratory collaborations with Duke Human Vaccine Institute, and core facilities comparable to those at Cold Spring Harbor Laboratory and Salk Institute. Shared resources encompass biorepositories, biostatistics cores partnering with Duke Clinical Research Institute, informatics platforms interoperable with Epic Systems Corporation instances, and regulatory support offices advising on Food and Drug Administration submissions and institutional review board processes similar to those at Mayo Clinic. The institute leverages computing resources affiliated with Duke University Information Technology Services and collaborates with regional networks including the Research Triangle Park innovation ecosystem.
Category:Research institutes in North Carolina