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| Coalition for Operational Research on Neglected Tropical Diseases | |
|---|---|
| Name | Coalition for Operational Research on Neglected Tropical Diseases |
| Formation | 2008 |
| Type | Non-profit research consortium |
| Leader title | Director |
Coalition for Operational Research on Neglected Tropical Diseases is a consortium focused on operational research to support programs addressing neglected tropical diseases. The coalition convenes actors from public health, global health, and scientific communities to guide implementation, evaluation, and policy for disease control and elimination. It engages stakeholders from international organizations, academic institutions, national programs, and philanthropic funders to translate evidence into practice.
The coalition was launched in 2008 following dialogues among stakeholders including the World Health Organization, Bill & Melinda Gates Foundation, Centers for Disease Control and Prevention, Global Alliance for Vaccines and Immunization, and national neglected tropical disease programs such as those in Uganda, Nigeria, and India. Early convenings involved researchers from London School of Hygiene & Tropical Medicine, Liverpool School of Tropical Medicine, and University of Washington, along with implementers from Sightsavers, RTI International, and Helen Keller International. The formation drew on precedents set by consortia like TB Alliance, Medicines for Malaria Venture, and networks including European & Developing Countries Clinical Trials Partnership and Special Programme for Research and Training in Tropical Diseases. Founding meetings featured representatives from ministries of health from Kenya and Mozambique and technical agencies such as PATH.
The coalition’s mission aligns with strategic aims advanced by entities such as World Health Assembly, Bill & Melinda Gates Foundation, and United Nations Development Programme to reduce the burden of neglected tropical diseases. Objectives include generating operational evidence for program managers of national neglected tropical disease initiatives, informing policy processes at World Health Organization, and supporting elimination targets akin to those set by London Declaration on Neglected Tropical Diseases. The coalition emphasizes translating research from partners like Johns Hopkins Bloomberg School of Public Health, Imperial College London, and Mahidol University into programmatic guidance for endemic countries including Bangladesh and Ethiopia.
Governance draws on models used by Gavi, the Vaccine Alliance and Global Fund to Fight AIDS, Tuberculosis and Malaria, with an advisory board comprising representatives from institutions such as WHO Department of Control of Neglected Tropical Diseases, Centers for Disease Control and Prevention, Bill & Melinda Gates Foundation, Sightsavers, Oxford University, and national disease control programs from Tanzania and Philippines. Membership includes academic partners like University of California, Berkeley, McGill University, and University of Liverpool; implementers such as Save the Children and United Nations Children's Fund; and technical partners like RTI International and FHI 360. Regional representation mirrors structures in African Union, Association of Southeast Asian Nations, and Pan American Health Organization.
Research priorities reflect agendas from World Health Organization roadmaps and targets similar to those in the London Declaration on Neglected Tropical Diseases, addressing diseases such as lymphatic filariasis, onchocerciasis, schistosomiasis, trachoma, and soil-transmitted helminths. Programs collaborate with laboratories at Institut Pasteur, Kenya Medical Research Institute, and Nagasaki University to study mass drug administration strategies, diagnostics, surveillance, and health systems integration. Priority activities include operational trials with partners like ICDDR,B, modeling work with Imperial College London and Institute for Disease Modeling, and implementation research with national programs in Cameroon and Ghana.
The coalition partners with multilaterals and funders including World Health Organization, Bill & Melinda Gates Foundation, United Nations Children's Fund, and World Bank as well as academic networks such as Consortium of Universities for Global Health and Tropical Disease Research Network. Collaborations extend to advocacy and implementation organizations like Sightsavers, Helen Keller International, RTI International, and PATH, and to national ministries of health in Uganda, Nigeria, and India. The coalition coordinates with drug donation programs run by pharmaceutical companies allied with the London Declaration on Neglected Tropical Diseases and with modeling consortia including Neglected Tropical Diseases Modelling Consortium.
The coalition has influenced guidelines and policies adopted by World Health Organization and national ministries, contributed to operational evidence used by programs in Tanzania and Ethiopia, and supported capacity building through training with partners such as Liverpool School of Tropical Medicine and London School of Hygiene & Tropical Medicine. Publications stemming from coalition-supported studies have appeared alongside work from Johns Hopkins Bloomberg School of Public Health, Imperial College London, and Institut Pasteur, informing mass drug administration schedules, surveillance thresholds, and cessation criteria referenced by World Health Assembly deliberations. Its collaborative projects have supported elimination milestones reported by countries including Nepal and Morocco.
Funding sources mirror those of global health consortia, including grants from Bill & Melinda Gates Foundation, project funds from USAID, and support from multilaterals such as World Bank and Global Fund to Fight AIDS, Tuberculosis and Malaria. Governance mechanisms include advisory and technical committees with representatives from World Health Organization, academic institutions like Oxford University and Imperial College London, and implementing partners such as Sightsavers and RTI International. Accountability frameworks draw on models used by Gavi, the Vaccine Alliance and Global Fund to Fight AIDS, Tuberculosis and Malaria to ensure transparency to national ministries and donor agencies such as National Institutes of Health.
Category:Neglected tropical disease organizations