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| Centre for Tropical Medicine and Global Health | |
|---|---|
| Name | Centre for Tropical Medicine and Global Health |
| Established | 2006 |
| Type | Research centre |
| Affiliation | University of Oxford |
| Location | Oxford, England |
Centre for Tropical Medicine and Global Health is an academic research centre affiliated with the University of Oxford that concentrates on infectious diseases, public health, and clinical tropical medicine. The centre integrates laboratory science, field epidemiology, and clinical trials to address diseases endemic in Sub-Saharan Africa, South Asia, and Southeast Asia, collaborating with global partners including the World Health Organization, Wellcome Trust, and Médecins Sans Frontières. Its work intersects with institutions such as London School of Hygiene & Tropical Medicine, Imperial College London, Harvard University, and Karolinska Institutet to translate research into policy adopted by agencies like the United Nations Children's Fund and the Bill & Melinda Gates Foundation.
The centre traces intellectual roots to the Liverpool School of Tropical Medicine and the historical expeditionary research of the Rockefeller Foundation in the early 20th century, formalizing as a consolidated unit within the University of Oxford in 2006 under leadership connected to figures from Mahidol University, Makerere University, and University of Cape Town. Early collaborations linked projects funded by the Wellcome Trust and grants from the European Commission to field sites in Kenya, Uganda, Bangladesh, and Thailand. Over successive strategic reviews the centre expanded programs influenced by global responses to outbreaks like Ebola virus epidemic in West Africa and the Zika virus epidemic, and by policy frameworks developed by the World Health Organization and the Global Fund. Prominent investigators have held visiting positions with Centers for Disease Control and Prevention, National Institutes of Health, and advisory roles to the UK Department for International Development and the Gavi, the Vaccine Alliance.
Research themes encompass malaria, neglected tropical diseases, antimicrobial resistance, and emerging viral infections, aligning projects with partners such as PATH, Clinton Health Access Initiative, and International Centre for Diarrhoeal Disease Research, Bangladesh. The centre conducts randomized controlled trials influenced by methodologies from Cochrane, ClinicalTrials.gov, and the European Medicines Agency to test interventions including vaccines developed with collaborators like GlaxoSmithKline and Pfizer. Epidemiological modeling efforts draw on techniques used by teams at Imperial College London, Los Alamos National Laboratory, and Johns Hopkins University to inform responses to epidemics such as COVID-19 pandemic, Cholera outbreaks, and seasonal Influenza pandemics. Programs addressing vector control work alongside institutions like Institut Pasteur, WHO Regional Office for Africa, and Africhol Consortium, while laboratory science leverages platforms pioneered at Sanger Institute, Wellcome Sanger Institute, and Broad Institute for genomic surveillance.
The centre provides postgraduate training integrated with the Nuffield Department of Medicine and degree programs at the University of Oxford, offering MSc and DPhil supervision and short courses in conjunction with London School of Hygiene & Tropical Medicine, University of Glasgow, and University of Edinburgh. Training emphasizes clinical skills informed by curricula from Royal College of Physicians, research design aligned with Council for International Organizations of Medical Sciences, and ethics frameworks used by World Medical Association and institutional review boards linked to Oxford Tropical Network. Fellowship schemes mirror models from the Wellcome Trust and Newton Fund and support placements at partner hospitals including Mulago National Referral Hospital, Queen Elizabeth Central Hospital, and Patan Hospital.
The centre's clinical work interfaces with the Oxford University Hospitals NHS Foundation Trust and contributes to patient care standards influenced by guidelines from National Institute for Health and Care Excellence, World Health Organization, and specialist recommendations from International Society of Travel Medicine. Clinical trials conducted at affiliated sites have tested therapeutics used in management of malaria, sepsis, and neglected diseases historically treated at centers such as Hospital for Tropical Diseases and clinics supported by Médecins Sans Frontières. Clinical capacity building includes training for clinicians from Ghana Health Service, Kenya Medical Research Institute, and Ministry of Health (Uganda) to implement protocols endorsed by European Society of Clinical Microbiology and Infectious Diseases.
Key partnerships include long-term field collaborations with Kenya Medical Research Institute, Malawi-Liverpool-Wellcome Trust Clinical Research Programme, Bangladesh Institute of Tropical and Infectious Diseases, and networks like the European & Developing Countries Clinical Trials Partnership. Strategic alliances with funders and agencies—Wellcome Trust, Bill & Melinda Gates Foundation, UK Research and Innovation, Global Fund—enable multicenter studies coordinated with consortia such as REACT and ISARIC. The centre also contributes to policy dialogues convened by WHO Strategic Advisory Group of Experts, the London Declaration on Neglected Tropical Diseases, and initiatives led by Coalition for Epidemic Preparedness Innovations.
Laboratory capabilities include molecular biology, immunology, and high-containment platforms comparable to facilities at Wellcome Sanger Institute and Institut Pasteur, with biobanking standards harmonized with the Global Biorisk Advisory Council and sample-sharing policies influenced by the Nagoya Protocol. Field infrastructure supports cohort studies and clinical trials across sites in Mozambique, Rwanda, and Cambodia with logistics coordinated via partners like Drive Health and regional research hubs at African Academy of Sciences. Computational resources employ bioinformatics pipelines used by Broad Institute and modeling tools from Centre for Mathematical Modelling of Infectious Diseases and Institute for Health Metrics and Evaluation.
Governance follows university statutes of the University of Oxford with advisory input from external boards including representatives from Wellcome Trust, Bill & Melinda Gates Foundation, World Health Organization, and national research councils such as Medical Research Council (UK). Funding streams comprise competitive grants from Wellcome Trust, European Research Council, UK Research and Innovation, philanthropic awards from Gates Foundation, and contracts with multilateral agencies like the Global Fund to Fight AIDS, Tuberculosis and Malaria. Financial oversight aligns with compliance frameworks used by Charity Commission for England and Wales and audit standards similar to those of National Audit Office (United Kingdom).
Category:Research institutes in Oxford