Andrew Ewing

Andrew Ewing
Name	Andrew Ewing
Occupation	Chemist; Neuroscientist
Institutions	University of Gothenburg; University of Pennsylvania; Swedish Research Council

Andrew Ewing is a chemist and neuroscientist known for research at the intersection of analytical chemistry, neurobiology, and biophysics. He has developed high-resolution electrochemical and mass spectrometric techniques to study neurotransmitter release, synaptic vesicles, and the molecular composition of secretory organelles. His laboratory has collaborated broadly with groups in Europe and North America on projects linking molecular measurements to cellular physiology.

Early life and education

Ewing completed undergraduate and graduate training that positioned him at the interface of analytical chemistry and neurobiology. He pursued doctoral studies at institutions with strong programs in mass spectrometry and electrochemistry, training under mentors associated with techniques used by researchers at Royal Society of Chemistry-affiliated laboratories and groups connected to European Molecular Biology Laboratory. Postdoctoral work involved collaborations with investigators engaged in studies related to synaptic transmission and cellular secretion at centers comparable to Max Planck Society institutes and research groups influenced by methodologies from Stanford University and Johns Hopkins University.

Academic and research career

Ewing has held faculty positions and leadership roles in departments that bridge chemistry and neuroscience, including appointments at universities in Scandinavia and the United States. He has led laboratories that integrate instruments and approaches associated with time-of-flight mass spectrometry, liquid chromatography, and microelectrode-based electrochemical detection. His career includes supervision of graduate students and postdoctoral fellows who have gone on to positions at institutions such as Harvard University, Massachusetts Institute of Technology, Karolinska Institutet, and national laboratories linked to European Research Council-funded programs. He has served on editorial boards of journals connected to societies like the American Chemical Society and contributed to panels organized by agencies such as the Swedish Research Council and funding bodies analogous to the National Institutes of Health.

Research contributions and notable publications

Ewing's work established methodological advances in single-cell and single-organelle analysis combining electrochemical amperometry, nanoelectrodes, and mass spectrometric readouts. He published studies characterizing exocytosis by measuring quantal release events with techniques related to those developed at laboratories influenced by John B. Fenn and Koichi Tanaka, and applying detection schemes akin to approaches from groups at University of California, Berkeley and Columbia University. His team reported measurements of catecholamine and peptide release from chromaffin cells and neuronal preparations, producing data cited alongside work from investigators at University of Oxford, University of Cambridge, and University of Chicago.

Representative publications include articles in journals comparable to Nature Communications, Proceedings of the National Academy of Sciences, Analytical Chemistry, and Journal of Neuroscience. These works detailed experiments on vesicular content heterogeneity, fusion pore dynamics, and chemical cytometry of synaptic vesicles, connecting to conceptual frameworks advanced by researchers at Max Planck Institute for Biophysical Chemistry and experimental paradigms used at Salk Institute for Biological Studies. Collaborations extended to groups researching neurodegenerative diseases and addiction at institutions like Karolinska Institutet and Yale University.

Awards and honors

Ewing's achievements have been recognized by membership in learned societies and by awards from organizations associated with analytical and neurochemical science. Honours include competitive research grants and prizes comparable to those offered by the Swedish Research Council, fellowships linked to the Royal Swedish Academy of Sciences, and accolades aligned with societies such as the Royal Society of Chemistry and the Biophysical Society. His laboratory's contributions have been highlighted at international conferences including meetings of the Gordon Research Conferences, International Union of Pure and Applied Chemistry, and specialized symposia associated with Society for Neuroscience.

Selected patents and inventions

The laboratory developed instrumentation and protocols for high-sensitivity detection of neurotransmitters and peptides, leading to patent filings and technology disclosures in areas related to nanoelectrode design, microfluidic sample handling, and coupling of electrochemical detection with mass spectrometry. These innovations parallel device concepts emerging from translational partnerships seen between universities and technology transfer offices at institutions such as Karolinska Institutet, University of Pennsylvania, and Chalmers University of Technology. Patents attributed to the group cover assays and components useful for single-vesicle analysis and rapid chemical cytometry workflows.

Personal life and affiliations

Ewing is affiliated with universities and research institutes in Europe and North America, participating in collaborative networks that include members from University of Gothenburg, University of Pennsylvania, Karolinska Institutet, Chalmers University of Technology, and consortia funded by the European Research Council. He engages in mentorship and outreach activities and has co-organized symposia with societies such as the Royal Swedish Academy of Sciences, American Chemical Society, and Society for Neuroscience.

Category:Chemists Category:Neuroscientists