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| Alexander Wilce | |
|---|---|
| Name | Alexander Wilce |
| Birth date | 1968 |
| Birth place | Boston, Massachusetts |
| Nationality | American |
| Occupation | Professor, Researcher, Author |
| Alma mater | Harvard University; University of Cambridge; Massachusetts Institute of Technology |
| Discipline | Cognitive neuroscience; Computational psychiatry |
| Institutions | Harvard Medical School; Massachusetts General Hospital; Wellcome Trust Centre for Neuroimaging |
Alexander Wilce is a cognitive neuroscientist and computational psychiatrist known for integrating neuroimaging, computational modeling, and clinical translation. His work bridges experimental neuroscience, psychiatric practice, and translational research programs, collaborating with major institutions and consortia to develop biomarkers and mechanistic models for affective disorders. Wilce has held faculty appointments and directed multi-site studies that influenced diagnostic approaches and treatment personalization.
Born in Boston, Massachusetts, Wilce attended Phillips Academy before matriculating at Harvard University where he studied psychology and philosophy. He completed postgraduate training at the University of Cambridge under advisors associated with the Wellcome Trust Centre for Neuroimaging and earned a doctorate at the Massachusetts Institute of Technology in cognitive neuroscience. During his graduate work he trained alongside researchers affiliated with McGovern Institute for Brain Research, Broad Institute, and clinical collaborators at Massachusetts General Hospital.
Wilce began his academic career as a junior faculty member at Harvard Medical School and served as a research fellow at the Wellcome Trust-funded research group at University College London. He later held appointments at the Massachusetts Institute of Technology Department of Brain and Cognitive Sciences and directed an interdisciplinary lab that partnered with investigators from National Institute of Mental Health, Stanford University, Yale University, Columbia University, and the University of Oxford. Wilce led multi-center trials in conjunction with clinical units at Beth Israel Deaconess Medical Center and McLean Hospital, and he served on advisory boards for the National Institutes of Health, the European Research Council, and the Simons Foundation.
Wilce’s research focused on neurocomputational models of emotion regulation, biomarkers for mood disorders, and the neural circuits underlying decision-making in psychiatric conditions. He published in venues such as Nature Neuroscience, The Lancet Psychiatry, Neuron, Proceedings of the National Academy of Sciences, and JAMA Psychiatry. His lab combined methods from functional magnetic resonance imaging (fMRI) work at facilities like Martinos Center for Biomedical Imaging with electrophysiology collaborations at Salk Institute and computational collaborations with groups at Google DeepMind and the Allen Institute for Brain Science. He contributed chapters to edited volumes alongside scholars from Princeton University, University of California, Berkeley, and University College London, and he was a frequent presenter at conferences including Society for Neuroscience, Organization for Human Brain Mapping, and the World Psychiatric Association.
Wilce received early career awards from the Klingenstein-Simons Foundation and a career development award from the National Institute of Mental Health. He was awarded a research grant from the Wellcome Trust and later a translational research prize from the American Psychiatric Association. His lab received project funding from the Simons Foundation and the Human Frontier Science Program, and he was elected a fellow of the Association for Psychological Science and a member of the American College of Neuropsychopharmacology.
Wilce lived in the Boston area and maintained collaborative ties with research centers in London, Cambridge (England), and San Diego. He balanced laboratory leadership with mentorship of graduate students from institutions including Harvard University, Massachusetts Institute of Technology, University of Cambridge, and Yale University. Outside academia he engaged with science outreach programs at the Smithsonian Institution and partnered with arts organizations such as the Museum of Science, Boston.
Wilce’s integrative approach influenced subsequent work on computational psychiatry, shaping how consortia such as the BRAIN Initiative and the Human Connectome Project prioritized translational biomarkers. His publications and collaborations helped steer clinical trial design at centers like Massachusetts General Hospital and informed machine learning applications developed in partnership with IBM Research and Microsoft Research. Students and postdoctoral fellows from his lab went on to faculty positions at Columbia University, Stanford University, King’s College London, and University College London, propagating his methodological emphasis on mechanistic modeling and multi-modal neuroimaging.
Category:American neuroscientists Category:Computational psychiatrists