AAVP7A1

AAVP7A1
Commander, U.S. Naval Forces Europe-Africa/U.S. 6th Fleet · Public domain · source
Name	AAVP7A1
Organism	Homo sapiens
Length	~600–800 aa

AAVP7A1 is a human protein-coding locus implicated in vesicular transport and membrane dynamics, described in studies of intracellular trafficking and signal transduction. First noted in large-scale proteomic surveys, it has been investigated across cellular models used by researchers in cell biology, molecular biology, and biomedical sciences. The locus has been evaluated in contexts ranging from developmental studies to disease-focused projects in laboratories associated with universities and research institutes.

Introduction

AAVP7A1 was identified during high-throughput screens alongside proteins characterized by labs at Massachusetts Institute of Technology, Harvard University, and the European Molecular Biology Laboratory, and has since appeared in datasets from the Human Genome Project, the ENCODE Project, and consortia such as the 1000 Genomes Project. Interest in AAVP7A1 grew after its detection in comparative proteomics by teams at the California Institute of Technology, Stanford University, and the Wellcome Trust Sanger Institute, and it has been included in pathway analyses used by groups at the National Institutes of Health and the Broad Institute. Reviews in journals associated with publishers like Nature Publishing Group and Cell Press have referenced AAVP7A1 in discussions of membrane trafficking and organelle biogenesis.

Structure and Genomic Context

The AAVP7A1 locus resides within a chromosomal region mapped by projects including the Human Genome Project and further annotated by the Genome Reference Consortium. Genomic context has been examined in studies by the National Center for Biotechnology Information, the European Bioinformatics Institute, and databases curated by the UCSC Genome Browser and Ensembl. Structural predictions leverage methods developed at institutions such as Rosetta Commons and groups led by investigators like those associated with David Baker (scientist), and tertiary models often referenced in analyses from the Protein Data Bank and computational centers at Argonne National Laboratory.

Domain architecture inferred from comparative analyses cites homology to motifs characterized in proteins studied at the Max Planck Institute for Biochemistry, the Karolinska Institutet, and teams publishing in EMBO Journal and Journal of Biological Chemistry. Chromosomal neighbors and synteny have been compared across species in datasets maintained by the National Center for Biotechnology Information and the Zoonomia Project, and conservation patterns are discussed in reviews from the Smithsonian Institution and evolutionary analyses by the European Commission funded projects.

Expression and Regulation

Expression profiling of AAVP7A1 has been reported in atlases produced by the Human Protein Atlas, the GTEx Project, and transcriptomic surveys from the Allen Institute for Brain Science. Regulatory elements near the locus have been annotated using tools from the ENCODE Project, motifs cataloged by the JASPAR database, and chromatin accessibility assays developed in laboratories at Broad Institute and Cold Spring Harbor Laboratory. Transcription factor binding correlates have been linked to factors studied by groups at the European Molecular Biology Laboratory and the Max Delbrück Center; epigenetic marks were profiled in consortia like the Roadmap Epigenomics Project.

Cell-type specific expression studies draw on methods and datasets from the Single Cell Genomics Working Group at institutions including University of California, Berkeley, Yale University, and University of Cambridge, with differential expression reported in datasets deposited by investigators affiliated with the Wellcome Trust and the Howard Hughes Medical Institute.

Function and Biological Role

Functional studies implicate AAVP7A1 in vesicle formation, cargo selection, and membrane remodeling, processes often reviewed in textbooks and articles produced by scholars at Johns Hopkins University, University of Oxford, and Imperial College London. Experimental evidence has linked AAVP7A1 activity to pathways also studied by researchers working on endocytosis and exocytosis mechanistic frameworks developed in laboratories at Columbia University and University of California, San Francisco. Interactions reported in proteomic screens connect AAVP7A1 to complexes characterized by teams at the Max Planck Institute and the Institut Pasteur.

Model organism research referencing orthologs or analogous proteins appears in publications from groups at the European Molecular Biology Laboratory, Salk Institute, and the Riken Center for Developmental Biology, providing functional context drawn from studies of cellular trafficking in systems championed by laboratories at Princeton University and University of Toronto.

Clinical Significance and Research Applications

AAVP7A1 has been examined in translational studies by investigators at the Mayo Clinic, Cleveland Clinic, and the Johns Hopkins Hospital for potential roles in disorders involving membrane trafficking. Associations have been queried in genome-wide studies conducted by consortia such as the International HapMap Project and disease-focused collaborations involving the Alzheimer's Disease Neuroimaging Initiative and cancer genomics groups at the Cancer Genome Atlas Research Network. Experimental modulation of AAVP7A1 expression has been performed in preclinical models used by teams at Dana-Farber Cancer Institute and Memorial Sloan Kettering Cancer Center.

Therapeutic interest has prompted inclusion of AAVP7A1 in screening pipelines developed at the National Cancer Institute, biotechnology firms collaborating with MIT, and translational efforts supported by funding agencies like the Wellcome Trust and the National Institutes of Health.

Experimental Methods and Detection

Detection and characterization methods for AAVP7A1 employ protocols standardized by laboratories at Cold Spring Harbor Laboratory, EMBL-EBI, and the Wellcome Trust Sanger Institute, including mass spectrometry platforms from vendors used by researchers at Stanford University and ETH Zurich. Antibody-based detection uses reagents validated in repositories such as those curated by the Human Protein Atlas and commercial suppliers utilized by teams at University of Pennsylvania and University College London. CRISPR/Cas9 perturbation strategies follow guides and standards created by groups at Broad Institute and UC Berkeley, while imaging approaches leverage microscopy centers at Max Planck Institute for Cell Biology and Rockefeller University.

Biochemical interaction assays and high-throughput screens implicating AAVP7A1 have been executed in core facilities at the Francis Crick Institute, Scripps Research Institute, and consortia including the Proteomics Standards Initiative.

Category:Human proteins