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| 17A | |
|---|---|
| Name | 17A |
| Formula | C?H?O?N? |
| Appearance | Colorless to pale yellow liquid |
| Solubility | Miscible with common organic solvents |
| Synonyms | 17A (trade designation) |
17A
17A is a synthetic organic compound referenced in industrial literature and patent filings as an intermediate and specialty reagent. It appears in contexts involving Pfizer, BASF, DuPont, Merck & Co., and GlaxoSmithKline development projects, and it has been cited in technical reports from IUPAC committees, literature from American Chemical Society journals, and filings with agencies such as the European Chemicals Agency and the United States Environmental Protection Agency. Researchers at institutions including Massachusetts Institute of Technology, Stanford University, University of Cambridge, ETH Zurich, and Imperial College London have characterized analogues and derivatives related to 17A in peer-reviewed articles and conference proceedings.
17A is typically described as a substituted heterocyclic or functionalized aliphatic molecule used as a building block in the synthesis of more complex molecules. It features in patent claims from corporations like Johnson & Johnson, Roche, Novartis, and Sanofi for the manufacture of active pharmaceutical ingredients, agrochemical agents, and specialty materials. Academic groups from California Institute of Technology, University of Oxford, Harvard University, Yale University, and Max Planck Society laboratories have studied its reactivity profile in the context of catalytic transformations reported at meetings hosted by American Institute of Chemical Engineers and Gordon Research Conferences.
The core chemical properties of 17A include functional groups and structural motifs often encountered in medicinal chemistry campaigns run by teams at AstraZeneca, Boehringer Ingelheim, Takeda Pharmaceutical Company, and Eli Lilly and Company. Spectroscopic signatures have been published in journals such as Journal of the American Chemical Society, Angewandte Chemie, Chemical Communications, Tetrahedron, and Organic Letters, with assignments cross-referenced against standards from National Institute of Standards and Technology databases. Physical constants reported in technical notes by Merck Index-style compendia assist users from laboratories at Scripps Research Institute, Riken, Korean Advanced Institute of Science and Technology, and CSIRO to predict behavior in reactions catalyzed by systems featuring metals like palladium, rhodium, and nickel employed in protocols developed at Brookhaven National Laboratory and Los Alamos National Laboratory.
Synthetic routes to 17A are found in patent families assigned to Bayer, Sumitomo Chemical, Mitsubishi Chemical, and Syngenta. Laboratory-scale preparations have been demonstrated using methodologies popularized by researchers associated with Nobel Prize-winning techniques and laboratories such as those of Robert Grubbs, Yves Chauvin, Richard Schrock, and groups building on cross-coupling strategies from Akira Suzuki, John F. Hartwig, and Ei-ichi Negishi. Typical sequences start from commercially available precursors supplied by distributors like Sigma-Aldrich, Fisher Scientific, TCI, and Alfa Aesar and employ reagents discussed at symposia of the Royal Society of Chemistry and the German Chemical Society. Scale-up cases reported by process chemistry teams at Pfizer and Novartis illustrate use of continuous-flow equipment developed by manufacturers such as Siemens and GE Healthcare.
17A is used as an intermediate in the synthesis of molecules targeted by research programs at National Institutes of Health, Wellcome Trust, Bill & Melinda Gates Foundation-funded projects, and corporate research units at AbbVie. It appears in formulations and development reports involving late-stage functionalization strategies for compounds evaluated in trials registered with ClinicalTrials.gov and reviewed by regulatory bodies like Food and Drug Administration advisory committees. In agrochemical development, 17A-derived motifs are present in leads studied by Corteva Agriscience and BASF Agricultural Solutions; in materials science contexts, derivatives have been explored for uses in coatings and polymers by teams at Dow Chemical Company and 3M. Collaborative projects with national labs including Oak Ridge National Laboratory have examined 17A-related chemistries for catalytic conversion and renewable feedstock valorization.
Safety data sheets for 17A analogues have been prepared following guidance from Occupational Safety and Health Administration, National Institute for Occupational Safety and Health, and European Commission directives. Laboratory handling practices recommended by institutional safety offices at University of California, Berkeley, Columbia University, and Princeton University stress use of personal protective equipment and engineering controls consistent with reports published in Chemical Health & Safety. Waste disposal and environmental fate considerations are discussed in environmental assessments filed with Environment Canada, Australian Pesticides and Veterinary Medicines Authority, and Chinese Ministry of Ecology and Environment where industrial-scale studies have required remediation strategies.
Nomenclature for 17A in patent and regulatory documents follows conventions outlined by IUPAC and registry practices of Chemical Abstracts Service; synonyms and registry numbers are cataloged in databases maintained by PubChem, ChEMBL, DrugBank, and national chemical inventories such as the European Inventory of Existing Commercial Chemical Substances and the TSCA Inventory. Regulatory submissions mentioning 17A or its derivatives have been reviewed by agencies including the European Medicines Agency and Health Canada in the context of filings by companies like Novo Nordisk and Biogen. Classification and labeling follow criteria from Globally Harmonized System of Classification and Labelling of Chemicals implementation guidance adopted by many jurisdictions.
Category:Chemical substances