Ann Marie Schmidt

Ann Marie Schmidt. She is an American physician-scientist renowned for her pioneering research into the molecular mechanisms underlying diabetic complications, particularly focusing on the Receptor for advanced glycation endproducts (RAGE). Her work has significantly advanced the understanding of how metabolic disorders like diabetes mellitus contribute to vascular disease, inflammation, and neurodegeneration. Schmidt's career has been primarily based at major academic institutions in New York City, including Columbia University and New York University.

Early life and education

Ann Marie Schmidt completed her undergraduate studies at the University of Pennsylvania. She then pursued her medical degree, earning an M.D. from the Columbia University College of Physicians and Surgeons. Following her medical training, she engaged in postdoctoral research to deepen her expertise in molecular biology and the pathophysiology of chronic diseases, setting the foundation for her future investigative career.

Career and research

Schmidt began her independent research career at Columbia University in the Department of Surgery and later at the College of Physicians and Surgeons. Her seminal work has centered on the role of RAGE, a multi-ligand receptor, in propagating inflammation and tissue injury in diabetic environments. She has extensively studied how the interaction between RAGE and its ligands, such as advanced glycation endproducts (AGEs) and S100 proteins, drives pathology in conditions like diabetic nephropathy, atherosclerosis, and Alzheimer's disease. Her laboratory's research has explored signaling pathways involving nuclear factor kappa B (NF-κB) and other mediators of oxidative stress. Schmidt continued her investigations as a professor at New York University School of Medicine, contributing to the Diabetes Research Program and collaborating with institutions like the American Diabetes Association. Her work has been published in high-impact journals including the Journal of Clinical Investigation, Nature Medicine, and Circulation Research.

Awards and honors

Throughout her career, Schmidt has received numerous accolades recognizing her contributions to biomedical science. She was a recipient of the prestigious American Heart Association Established Investigator Award. She also held a fellowship from the Irvington Institute for Immunological Research. Her research has been consistently funded by the National Institutes of Health and she has been invited to present her findings at major international conferences, including those organized by the European Association for the Study of Diabetes.

Personal life

Details regarding Ann Marie Schmidt's personal life are kept private. She has maintained a focus on her scientific career, mentorship, and leadership within the academic medical community.

Selected publications

* Schmidt, A.M., et al. "Isolation and characterization of two binding proteins for advanced glycosylation end products from bovine lung which are present on the endothelial cell surface." Journal of Biological Chemistry. * Schmidt, A.M., et al. "The endothelial cell binding site for advanced glycation end products consists of a complex: an integral membrane protein and a lactoferrin-like polypeptide." Journal of Biological Chemistry. * Schmidt, A.M., et al. "Activation of receptor for advanced glycation end products: a mechanism for chronic vascular dysfunction in diabetic vasculopathy and atherosclerosis." Circulation Research. * Schmidt, A.M., et al. "RAGE and Alzheimer's disease: a progression factor for amyloid-β-induced cellular perturbation?" Journal of Alzheimer's Disease.

Category:American medical researchers Category:Columbia University alumni Category:Diabetes researchers